The Phospho-MUC1 (T1224) Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to CA 15-3, CA15-3, CD227, KL-6, MAM6, MUC1, and Mucin 1. This antibody recognizes Human antigen. The Phospho-MUC1 (T1224) Antibody has been validated for the following applications: Dot Blot, ELISA, and Immunofluorescence.
Description
MUC1 is a member of the mucin family and encodes a membrane bound, glycosylated phosphoprotein. The protein is anchored to the apical surface of many epithelia by a transmembrane domain, with the degree of glycosylation varying with cell type. It also includes a 20 aa variable number tandem repeat (VNTR) domain, with the number of repeats varying from 20 to 120 in different individuals. The protein serves a protective function by binding to pathogens and also functions in a cell signaling capacity. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas